An obsessed Scientist tries to cure human deformities through DNA splicing, an obsession drawing him into a dark world where he experiments on the patients at Edgewood Asylum. Ignoring his pregnant wife Olivia, she comes to see him one night, but everything goes horribly wrong as Dr. Newman watches in horror as Olivia deliver their twins - One twin is a beautiful baby girl, the other a deformed creature that defies nature. 25 years later, on a dark road, a van breaks down. Young, beautiful Liz Holliman of the Roslyn Center for the Deaf is traveling with a group of young teens and her driver, ex-con, Jeff Thomas. With a flat tire, a storm and freezing temperatures, they must seek shelter. The group makes their way to an old abandoned building -- the Edgewood Asylum. Little do they know - evil awaits them. - Scientist becomes obsessed with DNA splicing.