When a group of wealthy trophy hunters genetically modify Graboid eggs to create the ultimate hunting experience, it isn't long before their prey escapes the confines of their small island and begin terrorizing the inhabitants of a nearby island research facility. The head of the research facility and her second-in-command Jimmy (Jon Heder) locate the one man who is an expert in killing Graboids: the one and only, and now reluctant, Burt Gummer (Michael Gross). Once on board, Burt leads the group in an all-out war against the larger, faster, and terrifyingly intelligent Graboids and the swiftly multiplying Shriekers! - Wealthy trophy hunters turn their sites on Graboids.