When Howard Brookner lost his life to AIDS in 1989, the 35-year-old director had completed two feature documentaries and was in post-production on his narrative debut, "Bloodhounds of Broadway" starring Madonna and Matt Dillon. Twenty-five years later, his nephew, director Aaron Brookner, sets out on a quest to find the lost negative of "Burroughs: The Movie", his uncle's critically-acclaimed portrait of legendary author William S. Burroughs with sound recorded by Jim Jarmusch and cinematography by Tom DiCillo. After a lengthy search, Howard's extensive archive is found in Burroughs' bunker, opening a window onto New York City's vibrant creative culture from the 1970s and '80s with key figures such as Andy Warhol, Frank Zappa, Allen Ginsberg, Laurie Anderson, Robert Wilson, Sara Driver, Patti Smith and many more. Uncle Howard is an award-winning Sundance documentary, executive produced by Jim Jarmusch, and a wide-ranging exploration of a beloved uncle's legacy. - A look at the life and death of young director.